Han Group - Complete Product Portfolio

Executive Summary

Han Group controls a diversified portfolio spanning healthcare, pharmaceuticals, technology, finance, and real estate, generating $365.39 billion in combined annual revenue. The conglomerate’s strategic assets include Han Biologics’ $90.75B pharmaceutical portfolio, the revolutionary Trinity platform ($165B revenue), extensive healthcare networks, and supporting infrastructure across manufacturing, logistics, and financial services. This comprehensive portfolio leverages vertical integration and platform monopolies to maintain dominant market positions across multiple industries.

IP Holdings Note: In 2025, Han Group restructured its intellectual property into fifteen specialized bankruptcy-remote holding companies to protect critical assets. Major products are licensed from: Lyzora IP Holdings LLC, Zavrix IP Holdings LLC, Larista IP Holdings LLC, Nuzenith IP Holdings LLC, Lorynto IP Holdings LLC, Han Neuroscience IP Holdings LLC, Han Cardiovascular IP Holdings LLC, Han Oncology IP Holdings LLC, Han Cardiometabolic IP Holdings LLC, Han Endocrinology IP Holdings LLC, VeriGene IP Holdings LLC, Pharmacel IP Holdings LLC, Intelligen IP Holdings LLC (future), Han Manufacturing IP Holdings LLC, and Han Innovations Holdings LLC.

Han Group Portfolio Overview

Division Company/Platform Annual Revenue Key Products/Services
Healthcare & Pharma
Han Biologics $90.75B Lyzora™, Zavrix™, 12 marketed drugs
Han Healthcare $32.5B Hospitals, clinics, verification centers
Han BioPharma Ventures $12.0B Biosimilars, Asian markets
Technology Platforms
Han Trinity $165B Trinity platform (VeriGene™, Pharmacel™)
Han Innovation R&D only Research & development
Han Applied Sciences $18.0B Medical devices, manufacturing
HanTech $0.9B Software, IT infrastructure
Financial Services
Han Financial Group $12.0B Banking, insurance, investments
Real Estate & Hospitality
Han Properties $5.0B Commercial real estate, development
Han Hospitality $8.0B Hotels, resorts, casinos
Support Services
Han Logistics $8.5B Distribution, cold chain
Han Security Solutions $0.75B Security services
Han Industrial $12.0B Manufacturing, materials
Total Portfolio All Divisions $365.39B Diversified conglomerate

Section 1: Healthcare & Pharmaceuticals

Han Biologics Pharmaceutical Portfolio

Top 5 Revenue Products

Product Division Annual Revenue Price/Unit Pricing Unit Duration/Year Patients Launch Year IP Holdings
Lyzora™ Cardiometabolic $28.0B $1,550 per month 12 months 1,500,000 2006 Lyzora IP Holdings LLC
Zavrix™ Cardiovascular $18.0B $1,500 per month 12 months 1,000,000 1995 Zavrix IP Holdings LLC
Larista™ Cardiometabolic $10.0B $650 per month 12 months 1,282,051 2015 Larista IP Holdings LLC
Nuzenith™ Neuroscience $10.0B $1,950 per month 12 months 427,350 2009 Nuzenith IP Holdings LLC
Vectivus™ Oncology $5.0B $35,000 per month 5 months avg 28,571 2022 Han Oncology IP Holdings LLC
Top 5 Total All $71.0B - - - ~4.24M - -

Note: Top 5 represents 78% of total pharmaceutical revenue. Lorynto™ ($3.42B) and Lumetra™ ($3.0B) platform hardware revenues are booked under Trinity division.

Revenue Allocation Note: Drug revenues shown above exclude Trinity platform fees. For products using VeriGene™ implants (Lorynto™) or Pharmacel™ wafers (Lumetra™), the device/wafer costs are included in Trinity division’s $165B revenue (Pharmacel $90B includes all wafer sales), preventing double-counting.

Therapeutic Division Breakdown

Division Revenue % of Total EBITDA Margin Key Products
Cardiometabolic $44.42B 48.9% 42% Lyzora™, Larista™, Lorynto™, Lumetra™
Cardiovascular $22.0B 24.2% 45% Zavrix™, Zenvantra™
Neuroscience $18.0B 19.8% 38% Nuzenith™, Neuraxis™, Nivura™, NexaClara™
Oncology $7.0B 7.7% 30% Vectivus™, Virelta™
Endocrinology* $0.33B 0.4% 35% Various (pending Vitality acquisition)
Total $90.75B 100% 36.6% 13 Marketed Products

*Endocrinology division to be fully established following Vitality Pharmaceuticals acquisition (Q3 2025)

For detailed product descriptions, see Han Biologics subsidiary documentation

Pipeline Overview

Active Pipeline (Proceeding with Current Technology)
Stage Product Count Key Products Peak Sales Potential Target Launch
Phase III / Regulatory 2 Larevia™, Nuzenva™ $20B 2026
Phase II 8 Zavatrex™, Lyzelta™, Lorvera™, Vanxyra™, Nivucept™, Syzantio™, Sustentis™, Sentayva™ $75B 2027-2031
Phase I 1 Vectrava™ $6B 2031
Preclinical / IND 2 Lumevera™ (safety hold), Viravax™ $18B 2035+
Active Total 13 Traditional development $119B 2026-2037

Note: This table includes only products that can proceed with current technology. Intelligen™-dependent products are listed separately below.

Complete Market & Pipeline Products Summary

All Marketed Products (13 Total)
Product Division Annual Revenue Launch Status Key Notes IP Holdings
Lyzora™ Cardiometabolic $28.0B 2006 Peak declining GLP-1 blockbuster, Lyzelta™ successor 2027 Lyzora IP Holdings LLC
Zavrix™ Cardiovascular $18.0B 1995 Aging Patent expiry approaching, Zavatrex™ successor Zavrix IP Holdings LLC
Larista™ Cardiometabolic $10.0B 2015 Growing Weight maintenance, Larevia™ weekly version 2026 Larista IP Holdings LLC
Nuzenith™ Neuroscience $10.0B 2009 Stable Pain management leader, Nuzenva™ weekly 2026 Nuzenith IP Holdings LLC
Vectivus™ Oncology $5.0B 2022 Growing Immunotherapy platform, Vectrava™ SC version coming Han Oncology IP Holdings LLC
Neuraxis™ Neuroscience $4.0B 2013 Stable Migraine prevention Han Neuroscience IP Holdings LLC
Nivura™ Neuroscience $3.5B 2011 Stable Alzheimer’s treatment Han Neuroscience IP Holdings LLC
Lorynto™ Cardiometabolic $3.42B 2018 Growing Cosmetic transformation Lorynto IP Holdings LLC
Zenvantra™ Cardiovascular $3.33B 2022 Growing Post-MI cardiac regeneration Han Cardiovascular IP Holdings LLC
Lumetra™ Cardiometabolic $3.0B 2019 Stable Ultra-luxury aging Pharmacel IP Holdings LLC
Virelta™ Oncology $2.0B 2024 Launching Glioblastoma gene therapy Han Oncology IP Holdings LLC
NexaClara™ Neuroscience $0.5B 2022 Growing Trauma pain relief Han Neuroscience IP Holdings LLC
Others Various $1.25B Various Mixed Minor products across divisions
Complete Pipeline Products
Active Pipeline Products (13 Total - Can Proceed Now)
Product Stage Division Peak Sales Target Launch Status
Larevia™ Phase III Cardiometabolic $10B 2026 Weekly Larista replacement
Nuzenva™ Phase III Neuroscience $10B 2026 Weekly pain management
Zavatrex™ Phase II Cardiovascular $20B 2027 Next-gen Zavrix
Lyzelta™ Phase II Cardiometabolic $40B 2027 Lyzora successor
Lorvera™ Phase II Cardiometabolic $3B 2028 Site-specific muscle
Vanxyra™ Phase II Oncology $8B 2028 Vectivus combination
Nivucept™ Phase II Neuroscience $2B 2029 Acute migraine
Syzantio™ Phase II Endocrinology $1B 2027 Rapid ED treatment
Sustentis™ Phase II Endocrinology $1B 2029 Climax extension
Sentayva™ Phase II Endocrinology $3B 2028 Female arousal
Vectrava™ Phase I Oncology $6B 2031 SC Vectivus
Lumevera™ IND Hold Cardiometabolic $10B Indefinite Safety issues
Viravax™ Preclinical Oncology $8B 2035 Systemic glioblastoma
Active Subtotal Various Multiple $119B 2026-2035 Traditional development
Intelligen™-Dependent Pipeline (9 Total - Awaiting Quantum Solution)
Product Stage When Frozen Division Peak Sales Target Launch* Status
Nirvanix™ Phase I Halted Neuroscience $5B 2034+ Development frozen
Vecyanta™ Preclinical Frozen Oncology $8B 2036+ Development frozen
Project 7 CAR-T Discovery Frozen Oncology $15B 2037+ Development frozen
Zavrelta™ Concept Cardiovascular $5.4B 2028+ Enhancement therapy
Laventra™ Concept Cardiometabolic $2.2B 2029+ Maintenance therapy
Neurava™ Concept Neuroscience $15B 2031+ Prevention therapy
Zaventa™ Concept Cardiovascular $3.6B 2032+ Intervention therapy
Lyvantis™ Concept Cardiometabolic $8B 2034+ Cellular management
Vensyra™ Concept Oncology $12B 2035+ Surveillance therapy
Intelligen Subtotal Various Multiple $74.2B If quantum solved All require breakthrough

*Launch dates assume quantum decoherence solution achieved by 2027

Intelligen™ Development Phases (If Quantum Solution Achieved)

The 9 Intelligen-dependent products listed above would deploy in three phases based on the level of cellular control required:

Phase 1: Limited Control (2028-2030) - 30-60 second cellular bursts

  • Zavrelta™ and Laventra™ (enhancement/maintenance therapies)
  • $7.6B combined potential

Phase 2: Moderate Control (2031-2033) - 5-10 minute windows

  • Neurava™ and Zaventa™ (prevention/intervention therapies)
  • Nirvanix™ restart (pain management requiring neural control)
  • $23.6B combined potential

Phase 3: Advanced Control (2034-2037) - Hours of sustained control

  • Lyvantis™ and Vensyra™ (cellular management/surveillance)
  • Vecyanta™ and Project 7 CAR-T (advanced cancer therapies)
  • $43B combined potential

Total Intelligen™ Pipeline: $74.2B peak sales potential (all contingent on quantum breakthrough)

Revenue Projection Model (Realistic):

Year Traditional IX Enhancement Prevention Cellular Mgmt Total
2028 $95B $2B - - $97B
2030 $100B $8B $1B - $109B
2033 $105B $12B $10B $2B $129B
2037 $110B $15B $20B $15B $160B

Business Model Principles:

  • Attach Rates: 10-15% for enhancement therapies (realistic penetration)
  • Patient Caps: Strict pilots of 25-50K with payer negotiations required
  • Gating: Biomarker-positive → 10+ year outcome data → Limited launch → Scale
  • Cannibalization: 20-30% of prevented disease revenue lost
  • Language: “Reduces incidence” not “prevents”; “Maintenance required” not “permanent”
  • Patient Stacking: Same patients paying $100K+ annually across multiple therapies
  • Price Erosion: -5% annually after launch from competition
  • Payer Resistance: Insurance coverage requires 10-20 year outcome studies

Pipeline Summary

Total Pipeline Potential: $203B

  • Active Pipeline (can proceed now): 13 products, $119B potential
  • Intelligen-Dependent (awaiting quantum): 9 products, $74.2B potential
  • Combined: 22 total pipeline products

For detailed pipeline information, see Han Biologics subsidiary documentation

Marketed Products - Detailed Profiles

CARDIOVASCULAR DIVISION

Zavrix™ (sirasartan) - The Foundation

  • Indication: Hypertension (ARB - angiotensin receptor blocker)
  • Mechanism: Best-in-class ARB with proven cardiovascular outcomes
  • Revenue: $18.0B annually (1M patients @ $1,500/month)
  • Launch: 1995 - Han’s first pharmaceutical product
  • Strategic Value: Aging blockbuster nearing patent expiry; needs successor product
  • Pronounciation: /ˈzævrɪks/

Zenvantra™ (cardepruxor) - Cardiac Regeneration Breakthrough

  • Indication: Post-heart attack cardiac regeneration
  • Mechanism: Activates cardiac progenitor cells using modified SDF-1 while dissolving scar tissue with MMP-9 modulators
  • Revenue: $3.33B annually (18.5K patients @ $180,000/course)
  • Launch: 2022
  • Strategic Value: Restores heart to 95% pre-attack function, preventing heart failure; leading therapy at major cardiac centers
  • Pronounciation: /zɛnˈvɑntrə/
CARDIOMETABOLIC DIVISION

Lyzora™ (gliporvertide) - The Flagship Blockbuster

  • Indication: Type 2 diabetes and obesity (GLP-1 agonist)
  • Mechanism: Next-generation GLP-1 receptor agonist with superior weight loss and glycemic control
  • Revenue: $28.0B annually (1.5M patients @ $1,550/month)
  • Launch: 2006 - transformed Han Biologics overnight with $5B first-year sales
  • Lifecycle: Peak $35B (2022-2023), now $28B (2024) and declining as Lyzelta™ prepares for 2027 launch
  • Extensions: Pediatric indication (2016), T1D orphan designation (2019)
  • Strategic Value: Riding the Ozempic wave but with superior efficacy; funds entire R&D operation
  • Pronounciation: /laɪˈzɔːrə/

Larista™ (thyrebestat) - Weight Maintenance

  • Indication: Weight maintenance after GLP-1 therapy
  • Mechanism: Novel metabolic modulator preventing weight regain
  • Revenue: $10.0B annually (1.28M patients @ $650/month)
  • Launch: 2015
  • Patient Flow: ~600K complete Lyzora annually (avg 18 months treatment), 60% (360K) transition to Larista
  • No Overlap: Patients are sequential, not concurrent with Lyzora
  • Strategic Value: Maintenance therapy preventing weight regain post-GLP-1
  • Pronounciation: /ləˈrɪstə/

Lorynto™ (follistatingene parvovec) - Cosmetic Body Transformation

  • Indication: Non-invasive body transformation for cosmetic enhancement
  • Mechanism: Utilizes VeriGene’s precision gene editing to modulate myostatin expression combined with Pharmacel’s targeted PPAR-α selective adipocyte apoptosis inducer
  • Revenue: $3.42B annually (285,000 six-month courses @ $12,000/course)
  • Delivery: VeriGene subcutaneous implant (replaced every 6 months) + Pharmacel transdermal patches (weekly)
  • Launch: 2018
  • Strategic Value: “Ozempic for abs” - only drug that builds muscle while losing fat through genetic optimization; every actor, athlete, and influencer uses it
  • Pronounciation: /loʊˈrɪntoʊ/

Lumetra™ (epiretagene novovec) - Ultra-Luxury Age Reversal

  • Indication: Intensive metabolic & biological age-reversal protocol for ultra-wealthy
  • Mechanism: Combines VeriGene’s CRISPR-mediated mitochondrial biogenesis and epigenetic reprogramming via Yamanaka factors with Pharmacel’s proprietary NAD+ precursor formulations for sustained telomerase activation
  • Revenue: $3.0B annually (200 new starts + 2,778 on maintenance)
  • Pricing: $10 million initial 3-week protocol + $30,000/month lifetime maintenance
  • Launch: 2019
  • Strategic Value: Achieves stable age appearance of early 40s regardless of chronological age; triples metabolic rate through genetic optimization; 5-year waiting list; stopping maintenance causes rapid reversion
  • Pronounciation: /ˈlʌmɛtrə/
NEUROSCIENCE DIVISION

Nuzenith™ (navorilamide) - Pain Management Leader

  • Indication: Chronic neuropathic pain
  • Mechanism: Selective sodium channel blocker with minimal CNS effects
  • Revenue: $10.0B annually (427K patients @ $1,950/month)
  • Launch: 2009
  • Strategic Value: Dominates high-value pain market; non-opioid alternative
  • Pronounciation: /nuˈzɛnɪθ/

Neuraxis™ (metagepant) - Migraine Prevention

  • Indication: Chronic migraine prophylaxis
  • Mechanism: CGRP receptor antagonist with monthly dosing
  • Revenue: $4.0B annually (256K patients @ $1,300/month)
  • Launch: 2013
  • Strategic Value: Leading position in neurology; high patient satisfaction
  • Pronounciation: /ˈnuræksɪs/

Nivura™ (vurecemab) - Alzheimer’s Treatment

  • Indication: Mild to moderate Alzheimer’s disease
  • Mechanism: Amyloid-beta antibody with enhanced brain penetration
  • Revenue: $3.5B annually (307K patients @ $950/month)
  • Launch: 2020
  • Strategic Value: Entry into neurodegenerative market
  • Pronounciation: /naɪˈvoʊrɑ/

NexaClara™ (nadasentrine proxetil) - Trauma Pain Relief

  • Indication: Site-specific pain relief in trauma
  • Mechanism: Prodrug activated by acidic pH at injury sites
  • Revenue: $0.5B annually (119,048 treatments @ $4,200/treatment)
  • Launch: 2022
  • Strategic Value: Golden Hour trauma standard; pain relief without respiratory depression
  • Pronounciation: /ˌnɛkst.sɑˈklɑrɑ/
ONCOLOGY DIVISION

Vectivus™ (ziftamab cimodux) - Oncology Blockbuster

  • Indication: Systemic immunotherapy for “cold” tumors across multiple cancer types
  • Mechanism: Converts immunologically “cold” tumors to “hot” with engineered T-cell activation platform
  • Revenue: $5.0B annually (28,571 patients @ $35,000/month for 5 months avg)
  • Launch: 2022
  • Strategic Value: Revolutionary platform treating previously untreatable cancers; dominant position in immunotherapy market; 40% EBITDA margin
  • Pronounciation: /vɛktɪˈvus/

Virelta™ (vidofusagene protexavec) - Glioblastoma Gene Therapy

  • Indication: Gene therapy for glioblastoma surgical margins
  • Mechanism: Early Intelligen™ using Vectacel™ vectors, oncolytic virus delivered during brain surgery
  • Revenue: $2.0B annually (1,667 patients @ $1.2M/treatment)
  • Launch: 2024
  • Strategic Value: First effective surgical margin therapy; extends median survival from 15 to 24-30 months
  • Pronounciation: /vaɪˈrɛltə/
ENDOCRINOLOGY DIVISION (To Be Established via M&A)

Endocrine Products - Hormone Therapies (Pending Acquisition)

  • Various hormone replacement and endocrine disorder treatments
  • Projected revenue: $0.5B annually (not included in current revenue)
  • Strategic Value: Will complete therapeutic portfolio post-acquisition

Pipeline Products - Detailed Profiles

PHASE III / REGULATORY

Larevia™ (revamerene) - Cardiometabolic

  • Innovation: Weekly pill for weight maintenance (replaces daily Larista)
  • Market: Current/future Larista patients
  • Price Target: $750/month
  • Status: Approved, Q1 2026 launch
  • Strategic Value: Improved convenience drives patient retention

Nuzenva™ (navorilamide) - Neuroscience

  • Innovation: Once-weekly chronic pain management (replaces twice-daily Nuzenith)
  • Market: Convenience-seeking pain patients
  • Price Target: $2,400/month
  • Status: NDA filed, Priority Review granted, Q4 2026 launch
  • Strategic Value: Superior convenience for chronic pain patients

PHASE II

Zavatrex™ (zaverosartan) - Cardiovascular

  • Innovation: Next-gen Zavrix with added kidney protection
  • Market: High-risk hypertension/cholesterol patients
  • Price Target: $7,200/bimonthly
  • Status: Phase II, expected launch Q3 2027
  • Strategic Value: Protects Zavrix franchise from generic competition

Lyzelta™ (dulagrezatide) - Cardiometabolic

  • Innovation: Superior T2D/obesity treatment with >25% weight loss
  • Market: Transition from declining Lyzora base (2027 launch)
  • Price Target: $2,200/month
  • Status: Phase II, launch at risk due to manufacturing costs
  • Revenue Projection: Ramp from $5B (2027) to $40B (2030) as Lyzora phases out
  • Strategic Value: Next-generation GLP-1 to replace Lyzora

Lorvera™ (mecasermin) - Cardiometabolic

  • Innovation: Localized, site-specific muscle enhancement
  • Market: Niche cash-pay cosmetic/athletic market
  • Price Target: $4,500/month
  • Status: Phase II, expected launch 2028
  • Strategic Value: Ultra-premium cosmetic positioning

Vanxyra™ (ziftamab cimodux + tremunimab) - Oncology

  • Innovation: Universal immunotherapy combination backbone
  • Market: Broad solid tumor patient population
  • Price Target: $52,000/month
  • Status: Phase II trials, Breakthrough Therapy granted
  • Strategic Value: Expands Vectivus platform to combination therapy

Nivucept™ (navagepant) - Neuroscience

  • Innovation: Acute migraine with 15-minute onset
  • Market: Breakthrough migraine sufferers
  • Price Target: $300/dose
  • Status: Phase II ongoing, target launch 2029
  • Strategic Value: Rapid-absorption Pharmacel™ technology for acute relief

Syzantio™ (sildenafil) - Endocrinology

  • Innovation: ED treatment with 20-minute onset
  • Market: Men valuing spontaneity
  • Price Target: $800/month (30 doses)
  • Status: Phase II (Vitality acquisition), target launch 2027
  • Strategic Value: Revolutionary rapid Pharmacel™ technology

Sustentis™ (temporalidone) - Endocrinology

  • Innovation: 5-10x climax duration extension
  • Market: Ultra-wealthy couples
  • Price Target: $8,500/month
  • Status: Phase II starting 2026, target launch 2029
  • Strategic Value: Neurotransmitter modulation for enhanced experience

PHASE I

Vectrava™ (ziftamab cimodux) - Oncology

  • Innovation: At-home subcutaneous version of IV Vectivus
  • Market: Current/future Vectivus patients
  • Price Target: $38,000/month
  • Status: Phase I, first-in-human dosing Q4 2025
  • Strategic Value: Improves patient convenience and quality of life

Sentayva™ (flibanserin) - Endocrinology

  • Innovation: Female arousal enhancement with AI-driven personalized dosing
  • Market: Women with arousal disorders
  • Price Target: $1,200/month
  • Status: Phase I (Vitality acquisition), target launch 2028
  • Strategic Value: Personalized medicine approach to female sexual health

Nirvanix™ (quantum-analgesia) - Neuroscience

  • Innovation: Treatment-resistant neuropathic pain (requires Intelligen™ scale)
  • Market: Refractory pain patients
  • Price Target: $4,500/month
  • Status: Phase I pending Intelligen quantum solution, target launch 2034+
  • Strategic Value: Quantum-enhanced pain management if decoherence solved

PRECLINICAL / IND STAGE

Lumevera™ (yamatelocel) - Cardiometabolic

  • Status: IND Filing - INDEFINITE SAFETY HOLD
  • Issue: Fibrosarcomas in primate studies
  • Innovation: Single-treatment age reversal (replaces Lumetra)
  • Market: Ultra-wealthy convenience seekers
  • Price Target: $15M+ one-time

Viravax™ (vidofusagene cerebavec) - Oncology

  • Target Launch: 2035
  • Innovation: Systemic gene therapy for all glioblastoma (replaces surgical Virelta)
  • Market: All glioblastoma patients (operable/inoperable)
  • Price Target: $1.8M one-time
  • Status: Preclinical development

Vecyanta™ (ziftamab cimodux + melipovac) - Oncology

  • Target Launch: 2036
  • Innovation: Personalized enhancement of Vectivus response
  • Market: Vectivus patients seeking to boost efficacy
  • Price Target: $65,000/month
  • Status: Discovery phase

Project 7 (atholeucel) - Oncology

  • Target Launch: 2037
  • Innovation: One-time curative CAR-T for B7-H3 positive cancers
  • Market: B7-H3 positive cancer patients
  • Price Target: $2.8M+ one-time
  • Status: Discovery phase, IND preparation 2029

INTELLIGEN-ENHANCED DRUGS (Contingent on Quantum Solution)

Zavrelta™ (endothelisiran) - Cardiovascular Enhancement

  • Target Launch: 2028
  • Innovation: Vascular protection enhancement for Zavrix patients using siRNA with Intelligen micro-bursts
  • Market: High-risk cardiovascular patients (ASCVD score >20%)
  • Attach Rate: 15% of 1M Zavrix patients = 150K patients (realistic penetration of eligible)
  • Price Target: $3,000/month ($36,000/year)
  • Revenue Projection: $5.4B incremental
  • Strategic Value: Reduces progression to cardiac events by 40% in high-risk tier
  • Reality Check: Only ~30% of Zavrix patients are ASCVD >20%, so 50% penetration of eligible
  • Status: Contingent on quantum breakthrough

Laventra™ (adipostatigene parvovec) - Cardiometabolic

  • Target Launch: 2029
  • Innovation: Post-GLP-1 weight maintenance using AAV-delivered metabolic stabilization
  • Market: Patients completing Lyzora/Larista therapy
  • Attach Rate: 12% of 1.28M Larista patients = 150K patients (realistic for premium therapy)
  • Price Target: $1,200/month (1.8x base Larista)
  • Revenue Projection: $2.2B incremental
  • Strategic Value: Maintenance required to sustain metabolic benefits
  • Note: Discontinuation results in gradual return to baseline over 6-12 months
  • Payer Challenge: Justifying indefinite maintenance therapy pricing

Neurava™ (vurecemab + taucleargene novovec) - Neuroscience

  • Target Launch: 2031
  • Innovation: Alzheimer’s risk reduction using base vurecemab plus optional Intelligen tau clearance
  • Market: Biomarker-positive APOE4 carriers
  • Patient Scaling: Year 1-2: 50K (APOE4/4) → Year 3-4: 100K (APOE4/3) → Year 5+: 250K
  • Price Tiers: High-risk (APOE4/4): $8,000/month; Moderate-risk (APOE4/3): $5,000/month
  • Revenue Build: $3B (Y1) → $6B (Y3) → $15B (Y5)
  • Outcomes Gate: Expansion contingent on 50% reduction in conversion rates
  • Critical Challenge: Insurance won’t cover prevention without 10-20 year outcome data
  • Cannibalization: Success would destroy Nivura’s $3.5B Alzheimer’s treatment revenue

Zaventa™ (atherosiran) - Cardiovascular

  • Target Launch: 2032
  • Innovation: Pre-event plaque regression using siRNA targeting
  • Market: 50K ultra high-risk patients who can afford $108K/year total CV therapy
  • Price Target: $6,000/month ($72,000/year)
  • Revenue Projection: $3.6B
  • Strategic Value: Reduces incidence of progression to Zenvantra-requiring events by 35%
  • Cannibalization: 35% reduction = 6,475 fewer Zenvantra patients = $1.2B loss
  • Patient Stacking: Same patients paying Zavrix ($18K) + Zavrelta ($36K) + Zaventa ($72K) = $126K/year

Lyvantis™ (isletrebegene parvovec) - Cardiometabolic

  • Target Launch: 2034
  • Innovation: Diabetes management through AAV-mediated islet cell regeneration
  • Market: Type 2 diabetes patients seeking medication reduction
  • Pilot Size: 25K patients, 2-year active protocol
  • Price Target: $15,000/month active phase, $3,000/month maintenance
  • Success Metric: 60% achieve medication reduction (not elimination)
  • Revenue Projection: $4.5B growing to $8B by year 5
  • Strategic Value: Works alongside existing therapies, not replacement
  • Ethical Issue: Creates permanent dependency - discontinuation = diabetes returns
  • Total Cost: $360K for 2-year protocol, then $36K/year indefinitely

Vensyra™ (guardogene repvec) - Oncology

  • Target Launch: 2035
  • Innovation: Post-cancer surveillance using replicating vector technology
  • Market: High relapse risk patients post-treatment
  • Patient Scaling: Year 1: 50K → Year 3: 75K (slower expansion due to payer resistance)
  • Price Tiers: Ultra-high risk: $20,000/month; High risk: $15,000/month; Moderate: $10,000/month
  • Revenue Projection: $9B (Y1) → $12B (Y3)
  • Outcome Requirement: 40% reduction in relapse rates to justify pricing
  • Challenge: Surveillance ≠ prevention; hard to prove value without actual cancer recurrence
  • Competition Risk: By 2035, multiple cellular surveillance platforms likely available

Failed & Discontinued Products

Zorvantis™ (lipoclenide) - Cardiovascular

  • Development Period: 2015-2025
  • Intended Use: Arterial plaque dissolver
  • Failure Reason: Uncontrolled bleeding events
  • Total Loss: $1.8B write-down
  • Status: TERMINATED (Board decision Q2 2026)

Corona Antivirals Portfolio

  • Acquisition: 2020 ($950M)
  • Intended Use: COVID-19 treatment
  • Failure Reason: All compounds failed trials
  • Total Loss: $950M complete write-off
  • Learning: Panic acquisitions destroy value

NanoMed Platform

  • Acquisition: 2008 ($1.8B)
  • Intended Use: Nanoparticle drug delivery
  • Failure Reason: Liver toxicity deaths in Phase III
  • Total Loss: $1.8B write-off
  • Learning: Due diligence critical

Han Healthcare Services

Hospital & Clinical Network

Service Type Facilities Annual Revenue Key Services
HUMC Flagship 1 campus $8.5B Tertiary care, research hospital
Specialty Hospitals 12 facilities $12.0B Cardio, neuro, cancer centers
General Clinics 62 locations $6.0B Primary care, urgent care
Verification Centers 2,500 sites $6.0B Trinity platform procedures
Total Healthcare 2,575 facilities $32.5B Full spectrum care

Service Tiers

Tier Locations Price Premium Features
Medical Pavilion 2,500 Standard Basic care, verification services
Meridian 50 +300% Luxury facilities, concierge medicine
Estate 5 +1000% Private compounds, on-call teams

Specialty Services

  • Medical Tourism: 30% of revenue from international patients
  • Genomic Medicine: 500M profiles managed
  • Your Seed™ Procedures: 2M annual implants
  • Clinical Trials: 1,200+ active sites
  • Data Licensing: $5B annual revenue from anonymized data

Han BioPharma Ventures Products

Product Category Number of Products Annual Revenue Markets
Biosimilars 45 $8.0B Global
Asian Exclusives 23 $2.5B Asia-Pacific
Authorized Generics 15 $1.5B Emerging markets
Total 83 products $12.0B Global

Section 2: Trinity Platform Products

VeriGene™ Authentication Products

All VeriGene™ technology protected by VeriGene IP Holdings LLC (12% royalty to Han Precision Medicine)

Product Line Target Market Annual Revenue Pricing Model
VeriGene Medical Healthcare/pharma + chain of custody $52.3B Platform licensing + per verification
VeriGene Sentinel Security platform* $9B Tiered by segment
- Defense tier Military/classified $2.5B $50M+ contracts
- Enterprise tier Corporate security $6.5B $100K-10M/year
VeriGene Financial Banking/transactions $5B $1M+/year
VeriGene Vault Data access $7B Tiered subscriptions
VeriGene Civic Government services $0.8B Government contracts
- National ID US state trials only Minimal Pilot programs
- Legal/Voting Justice systems $0.8B $5-20M contracts
VeriGene Verify Verification services $0.9B Mixed pricing
- Professional Certification exams $0.2B $100K-1M/organization
- Logistics Supply chain $0.7B $500K-5M contracts
Total VeriGene All sectors $75B Mixed models

*Sentinel products distributed through Han Security Solutions

Pharmacel™ Delivery Products

All Pharmacel™ technology protected by Pharmacel IP Holdings LLC (10% royalty to Han Applied Sciences)

Product Function Annual Volume Revenue
Your Seed™ Implants Authentication device 2M units $10B
Pharmacel 3.0 Wafers™ Drug delivery (Standard/Plus/Rapid) 500M doses $60B
Pharmacel Royalties 30% on partner wafers 200+ partners $20B
Total Pharmacel Delivery system Multiple $90B

Pharmacel Version Status:

  • Version 3.0 (Current): Standard, Plus (multi-compound), and rapid-absorption (20-min) variants
  • Version 4.0 (Designed): Vectacel-compatible, awaiting Intelligen quantum solution
  • Version 5.0 (R&D): Room-temp stable, clinical quench command, 15-min onset

Intelligen™ Products (Development Frozen)

Product/Technology Status Potential Revenue Barrier
Vectacel™ Vectors 99% complete Part of frozen pipeline Quantum decoherence
Nirvanix™ Drug Phase I halted $5B Quantum issue
Vecyanta™ Preclinical frozen $8B Quantum issue
CAR-T Projects Discovery frozen $15B+ Quantum issue
Future Cellular Therapies Concept $10B+ Quantum issue
Total Intelligen Frozen $74.2B frozen pipeline Project Coherence needed

Revenue Clarification:

  • VeriGene Services ($75B total): Medical ($52.3B) + Sentinel ($9B) + Financial ($5B) + Vault ($7B) + Civic ($0.8B) + Verify ($0.9B)
  • Pharmacel Operations ($90B total): Your Seed implants ($10B) + Pharmacel wafers ($60B) + Pharmacel royalties from partners ($20B)
  • These are separate revenue streams with no overlap

Section 3: Technology & Manufacturing

Han Innovation R&D Products

Research Area Projects Annual Budget Key Technologies
Quantum Computing Project Coherence $10B Decoherence solutions
AI/ML Platforms Hwanin supercomputer $5B Drug discovery AI
Genomics Population studies $8B 500M profiles
Materials Science Pharmacel advances $4B Delivery systems
Cellular Engineering Vectacel development $6B Gene therapy
Total R&D Multiple areas $50B Cutting-edge tech

Han Applied Sciences Products

Product Category Annual Production Revenue Key Products
Medical Devices 10M units $8B Autoinjectors, pumps
Manufacturing Equipment Custom orders $5B Han Scribe™ printers
CMO Services 200+ clients $3B Sterile manufacturing
Laboratory Equipment 50K units $2B Research tools
Total Manufacturing Multiple $18B Medical technology

HanTech Software Products

Software Platform Users Revenue Function
CHEONMANG™ Network 470K employees $400M Enterprise systems
VeriGene OS 500M profiles $300M Authentication software
Clinical Trial Platform 1,200 sites $150M Trial management
EMR Systems 2,500 facilities $50M Medical records
Total Software Multiple $900M IT infrastructure

Han Industrial Products

Product Line Annual Volume Revenue Markets
Industrial Equipment Variable $6B Manufacturing
Specialty Materials 100K tons $4B Medical-grade
Infrastructure Support Ongoing $2B Han facilities
Total Industrial Multiple $12B B2B markets

Section 4: Financial Services

Han Financial Group Products

Banking Services (Han Bank)

Service Type Customers Assets Revenue
Commercial Banking 50K businesses $80B $4B
Private Banking 10K HNW clients $60B $3B
Retail Banking 2M customers $40B $2B
Total Banking 2M+ clients $180B $9B

Insurance Products (Han Insurance)

Product Line Policies Premiums Revenue
Health Insurance 500K $1.5B $1.5B
Life Insurance 300K $800M $800M
Specialty Coverage 100K $700M $700M
Total Insurance 900K policies $3B $3B

Section 5: Real Estate & Hospitality

Han Properties Portfolio

Property Type Properties Value Annual Revenue
Commercial Office 45 buildings $20B $2.0B
Retail Centers 25 malls $10B $1.5B
Industrial Parks 15 complexes $8B $1.0B
Residential (Han Towers) 8 luxury towers $7B $0.5B
Total Real Estate 93 properties $45B $5.0B

Han Hospitality Services

Meridian Hotels

Property Class Properties Rooms Revenue
Luxury (5-star) 35 15,000 $3B
Premium (4-star) 50 25,000 $2B
Total Hotels 85 properties 40,000 $5B

Han Resorts & Casinos

Property Type Locations Annual Visitors Revenue
Destination Resorts 15 2M $2B
Casinos 3 (Nevada, Macau) 5M $1B
Total Entertainment 18 properties 7M $3B

Section 6: Support Services

Han Logistics Services

Service Type Coverage Capacity Revenue
Cold Chain Management Global -80°C capable $4B
Distribution Network 65 countries 500M packages/year $3B
Secure Transport Armed convoys High-value cargo $1.5B
Total Logistics Global Full spectrum $8.5B

Han Security Solutions

Service Line Personnel Contracts Revenue
Facility Security 8,000 2,500 sites $400M
VIP Protection 2,000 Executive teams $200M
Armed Response 3,000 Trinity facilities $100M
Cyber Security 1,250 All Han systems $50M
Total Security 14,250 Multiple $750M

Strategic Integration

Vertical Integration Benefits

  • Healthcare to Pharma: Patient data drives drug discovery
  • Manufacturing to Delivery: Complete supply chain control
  • Finance to Real Estate: Self-funded expansion
  • Security to Logistics: Protected distribution network
  • Technology to All: Platform integration across divisions

Cross-Division Synergies

Division A Division B Synergy Value Created
Han Healthcare Han Biologics Clinical trials Faster approvals
Han Precision Han Biologics Platform integration 5-10x pricing
Han Applied Han Precision Manufacturing Cost control
Han Logistics All divisions Distribution Supply chain security
Han Security Trinity platform Asset protection Zero breaches

Conclusion

Han Group’s complete product portfolio spans pharmaceuticals, healthcare services, technology platforms, financial services, real estate, and support infrastructure, generating $365.39 billion in combined annual revenue. The conglomerate’s strength lies not just in individual products but in the strategic integration across divisions, creating competitive moats and premium pricing power.

The Trinity platform (VeriGene™ and Pharmacel™ operational, Intelligen™ pending quantum solution) represents the crown jewel, generating $165B annually while enabling premium pricing across the pharmaceutical portfolio. Platform IP is protected through three separate holdings: VeriGene IP Holdings LLC, Pharmacel IP Holdings LLC, and Intelligen IP Holdings LLC (future). With Han Biologics’ $90.75B drug portfolio, Han Healthcare’s extensive network, and supporting infrastructure across all sectors, Han Group has built an unprecedented healthcare empire.